Search results for "Adverse Events"
OPAT has similar safety, lower costs versus inpatient antibiotic therapy
Patients receiving outpatient parenteral antimicrobial therapy (OPAT) after hospitalization for bacterial infection had 90-day adverse event rates of 35.6% compared to 39.0% in those who stayed in the hospital for parenteral antimicrobial therapy, a retrospective Canadian study found.
https://acphospitalist.acponline.org/archives/2022/04/27/opat-has-similar-safety-lower-costs-versus-inpatient-antibiotic-therapy.htm
27 Apr 2022
Gram stain-guided antibiotics for VAP noninferior to guideline-based therapy
Compared with guideline-based treatment, treatment guided by Gram staining significantly reduced use of broad-spectrum antibiotics and yielded similar clinical responses in patients with ventilator-associated pneumonia (VAP), a Japanese trial found.
https://acphospitalist.acponline.org/archives/2022/04/13/gram-stain-guided-antibiotics-for-vap-noninferior-to-guideline-based-therapy.htm
13 Apr 2022
New heart failure indication for SGLT-2 inhibitor
In addition to approving a sodium-glucose cotransporter-2 (SGLT-2) inhibitor for use in heart failure with preserved ejection fraction, the FDA recently warned about certain ventilators failing and a possible risk of cancer with a lymphoma medication.
https://acphospitalist.acponline.org/archives/2022/03/16/new-heart-failure-indication-for-sglt-2-inhibitor.htm
16 Mar 2022
ACP reviews evidence on remdesivir for inpatients, updates practice points
The College's updated systematic review found that a 10-day course of remdesivir probably results in little to no mortality reduction but does probably moderately increase the proportion of patients recovered by day 29 and may shorten length of stay.
https://acphospitalist.acponline.org/archives/2022/03/02/free/acp-reviews-evidence-on-remdesivir-for-inpatients-updates-practice-points.htm
2 Mar 2022
There will be (less) blood
A new patient blood management program reduced transfusions, length of stay, and cost at one hospital.
https://acphospitalist.acponline.org/archives/2022/02/16/there-will-be-less-blood.htm
16 Feb 2022
Research on CPAP, HFNO, IVIG, and lung transplants for COVID-19
One study found that continuous positive airway pressure (CPAP) outperformed conventional oxygen, but high-flow nasal oxygen (HFNO) did not. Another found no benefit from hyperimmune IV immunoglobulin (IVIG) in hospitalized patients. Two analyses showed good outcomes from lung transplants in COVID-19 patients.
https://acphospitalist.acponline.org/archives/2022/02/02/free/research-on-cpap-hfno-ivig-and-lung-transplants.htm
2 Feb 2022
Microbiome therapeutic reduced risk of recurrent C. difficile infection in phase 3 trial
An industry-funded trial of patients with recurrent Clostridioides difficile infection who received standard-of-care treatment with antibiotics found that those who also received the investigational drug had a 68% lower risk of recurrence than those who received placebo.
https://acphospitalist.acponline.org/archives/2022/01/26/microbiome-therapeutic-reduced-risk-of-recurrent-c-difficile.htm
26 Jan 2022
Balanced electrolyte solution didn't improve outcomes in ICU patients
A randomized trial in Australia and New Zealand found similar rates of 90-day mortality and new renal replacement therapy whether ICU patients were given a balanced multi-electrolyte solution (Plasma-Lyte 148) or saline.
https://acphospitalist.acponline.org/archives/2022/01/19/balanced-electrolyte-solution-didnt-improve-outcomes-in-icu-patients.htm
19 Jan 2022
Convalescent plasma did not facilitate recovery in COVID-19 inpatients, trial finds
There was a suggestion of benefit from plasma in patients treated earlier in the pandemic, before remdesivir and corticosteroids became the standard of care, according to exploratory analyses of this multicenter study.
https://acphospitalist.acponline.org/weekly/archives/2021/12/15/2.htm
15 Dec 2021
Catheters, antibiotics recalled
Recalls, warnings, and approvals.
https://acphospitalist.acponline.org/archives/2021/11/fda-update-catheters-antibiotics-recalled.htm
15 Nov 2021