Search results for "Antibiotics"
Phase 3 trial finds new antibiotic noninferior to daptomycin for MRSA
An industry-funded trial compared ceftobiprole, a cephalosporin, to daptomycin plus optional aztreonam in adults with complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus (MRSA).
https://acphospitalist.acponline.org/archives/2023/10/04/phase-3-trial-finds-new-antibiotic-noninferior-to-daptomycin-for-mrsa.htm
4 Oct 2023
First-line antibiotic options for CAP on the wards show similar mortality rates
A large retrospective study of patients with community-acquired pneumonia (CAP) found similar inpatient mortality with a beta-lactam plus a macrolide, a beta-lactam plus doxycycline, or a respiratory fluoroquinolone. A beta-lactam alone appeared less effective.
https://acphospitalist.acponline.org/archives/2023/08/23/first-line-antibiotic-options-for-cap-on-the-wards-show-similar-mortality-rates.htm
23 Aug 2023
Time to antibiotics matters for septic shock, not so much for sepsis without shock
Every hour that antibiotics were delayed was associated with higher mortality from septic shock, but patients with sepsis and no shock only had elevated risk of death if their antibiotics were not administered within six hours, according to a new analysis.
https://acphospitalist.acponline.org/archives/2023/08/09/time-to-antibiotics-matters-for-septic-shock-not-so-much-for-sepsis-without-shock.htm
9 Aug 2023
New antibiotic approved for hospital-acquired pneumonia
The FDA approved sulbactam and durlobactam for injection to treat hospital-acquired or ventilator-associated pneumonia caused by susceptible strains of Acinetobacter baumannii-calcoaceticus complex, among other recent actions.
https://acphospitalist.acponline.org/archives/2023/07/05/new-antibiotic-approved-for-hospital-acquired-pneumonia.htm
5 Jul 2023
Hypercalcemia from calcium sulfate antibiotic beads
A patient was admitted with right hip pain from a chronic prosthetic joint infection.
https://acphospitalist.acponline.org/archives/2023/05/31/free/hypercalcemia-from-calcium-sulfate-antibiotic-beads.htm
31 May 2023
Less definitely more in antibiotics
Review some common inpatient conditions that can be safely treated with shorter durations of antibiotics, reducing adverse events and costs.
https://acphospitalist.acponline.org/archives/2023/05/17/less-definitely-more-in-antibiotics.htm
17 May 2023
Prophylactic antibiotics did not improve survival in severe alcohol-related hepatitis
A double-blind randomized trial found no significant differences in all-cause mortality between hospitalized participants who received amoxicillin-clavulanate in addition to prednisolone versus prednisolone alone.
https://acphospitalist.acponline.org/archives/2023/05/17/prophylactic-antibiotics-did-not-improve-survival-in-severe-alcohol-related-hepatitis.htm
17 May 2023
Procalcitonin algorithm reduced antibiotic use in COVID-19 inpatients
A Dutch intervention used procalcitonin levels in inpatients with COVID-19 to guide antibiotic use, with an algorithm discouraging prescriptions if levels were less than 0.25 ng/mL and recommending antibiotics for patients with levels above 0.5 ng/mL.
https://acphospitalist.acponline.org/archives/2023/05/03/free/procalcitonin-algorithm-reduced-antibiotic-use-in-covid-19-inpatients.htm
3 May 2023
Antibiotic regimens differ in associated risk of AKI in critically ill patients
Vancomycin and piperacillin/tazobactam were associated with a higher risk of acute kidney injury (AKI) than either vancomycin and cefepime or vancomycin and meropenem in ICU patients, particularly at longer durations and in those with normal kidney function on admission.
https://acphospitalist.acponline.org/archives/2023/04/19/antibiotic-regimens-differ-in-associated-risk-of-aki-in-critically-ill-patients.htm
19 Apr 2023
Similar odds of recurrence with 10 vs. 14 days of antibiotics for complicated UTI with bacteremia
A study of 24 U.S. hospitals also found that in patients with complicated urinary tract infection (UTI) who receive beta-lactams or highly bioavailable oral agents, a seven-day course may be sufficient.
https://acphospitalist.acponline.org/archives/2023/01/25/similar-odds-of-recurrence-with-10-vs-14-days-of-antibiotics-for-complicated-uti-with-bacteremia.htm
25 Jan 2023