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RSV vaccine news, Entresto generic approval

The respiratory syncytial virus (RSV) vaccine by Moderna was newly approved for patients ages 60 years and older, while approval of the GlaxoSmithKline vaccine was expanded to ages 50 to 59 years, among other recent actions by the FDA.

Continuous infusion may provide benefit over intermittent in antibiotics for sepsis

A new randomized trial found a nonsignificant decrease in mortality with continuous infusion of beta-lactams for ICU patients with sepsis, but a new review that included the study showed a significant effect on mortality and cure rates with prolonged versus intermittent infusion.

Beta-lactam de-escalation associated with lower risk of new drug resistance in sepsis

Hospitalized patients with sepsis were less likely to develop new drug-resistant, gram-negative bacteria within 60 days if their antibiotics were de-escalated (according to a beta-lactam spectrum score) rather than continued at the same level, a retrospective study found.

IV amino acids may decrease AKI risk after cardiac surgery

Acute kidney injury (AKI) occurred in 26.9% of patients randomized to IV amino acids, 2 g/kg of ideal body weight per day, for up to 72 hours after surgery versus 31.7% of those who received Ringer's solution in a recent trial.

Respiratory Infections | June 19, 2024 | FREE
Most ACP Hospitalist content is available exclusively to ACP Members. This article is free to the public.

Fungal, bacterial pathogens in lungs differ in severe influenza versus COVID-19

Potential bacterial pathogens and aspergillosis were detected in 20% and 38% of patients with influenza and 37% and 31% of those with COVID-19, respectively, in a recent Belgian study.

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Every week, ACP Hospitalist posts a question about the previous week's issue. See how well you remember what you've read compared to other readers.

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Connecting with subspecialists on the outside

Freeing up an inpatient bed in a crowded hospital can sometimes be as simple as getting in touch with a subspecialist.

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Brief Case | June 12, 2024 | FREE
Most ACP Hospitalist content is available exclusively to ACP Members. This article is free to the public.

Dapsone-induced methemoglobinemia and hemolytic anemia

A patient being treated for lupus with cutaneous manifestations presented with gradual shortness of breath of about a month's duration.

Continuing metformin linked with lower risk of hospital-acquired complications

Patients who continued metformin upon admission had a lower likelihood of in-hospital complications than matched controls without diabetes, while diabetic patients who discontinued the drug during hospitalization had higher risk than matched controls.

Glucocorticoids prescribed to 1 in 9 ward patients with CAP, real-world data suggest

Glucocorticoids were prescribed in 11.1% of patients hospitalized on medical wards with community-acquired pneumonia (CAP) between 2010 and 2020, and these patients had higher inpatient mortality, data from seven Canadian hospitals showed.

Coronavirus | June 12, 2024 | FREE
Most ACP Hospitalist content is available exclusively to ACP Members. This article is free to the public.

Admission of COVID-19 patients to SNFs likely increased cases and related deaths

Skilled nursing facilities (SNFs) that admitted patients with COVID-19 had 6.94 additional new cases per 100 residents than similar facilities that didn't admit patients known to be positive, a study from June 2020 to March 2021 found.

Scores for infective endocarditis in bacteremia patients compared

The HANDOC score has high negative predictive value for identifying infective endocarditis and the 2023 Duke criteria from the International Society of Cardiovascular Infectious Diseases beat two other versions for diagnosing the disorder in patients with strep bacteremia, a Swiss study found.

Digging into the gender quality divide

There are lessons for all in a recent study that found female patients had lower mortality with female hospitalists, says one of the authors.

Photo courtesy of Dr Tsugawa

On to chronic respiratory failure

Distinguish between hypoxemic and hypercapnic chronic respiratory failure and recognize acute-and-chronic respiratory failure.


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