One international trial found higher 28-day mortality in ICU patients randomized to a vitamin C infusion compared to placebo, while another showed that 90-day mortality rates were similar when septic shock patients were treated with a standard or restrictive IV fluid strategy.
A randomized clinical trial at 11 U.S. ICUs found no significant difference in cardiovascular (CV) collapse or death at 28 days between critically ill adults who received a 500-mL IV bolus before induction of anesthesia for tracheal intubation and those who did not.
The accuracy of using guideline-recommended thresholds of N-terminal pro-B-type natriuretic peptide (NT-proBNP) alone to diagnose acute heart failure varied by patient age and other characteristics, including body mass index and renal impairment, a study found.
Patients with complex medication regimens had increases in mortality risk and ICU length of stay in a retrospective study. They also received more interventions from pharmacists, but a higher patient-to-pharmacist ratio was associated with fewer of these interventions.