Search results for "Research Summaries"
Two new studies provide potentially practice-changing evidence in shock care
One trial found that basing septic shock resuscitation on capillary refill time was noninferior to usual care, while another found similar mortality in shock patients whether or not they were randomized to automatically receive an arterial catheter within four hours.
https://acphospitalist.acponline.org/archives/2025/11/05/two-new-studies-provide-potentially-practice-changing-evidence-in-shock-care.htm
5 Nov 2025
Patient census but not days on service linked with hospitalist decision fatigue
The odds of a decision fatigue event were 1.58 times greater with a patient census above 13 patients, according to a study of 43 hospitalists caring for 2,081 patients.
https://acphospitalist.acponline.org/archives/2025/11/05/patient-census-but-not-days-on-service-linked-with-hospitalist-decision-fatigue.htm
5 Nov 2025
New version of the SOFA score developed, validated
The Sequential Organ Failure Assessment (SOFA)-2 score includes the same six organ domains but realigns the scoring within domains and addresses advances in medical care since the original score was developed.
https://acphospitalist.acponline.org/archives/2025/11/05/new-version-of-the-sofa-score-developed-validated.htm
5 Nov 2025
Hospitalist handoffs often suboptimal for patients with limited English proficiency
To improve them, a research team recommended using a standardized tool that incorporates language needs, health literacy, cultural context, and family involvement.
https://acphospitalist.acponline.org/archives/2025/11/05/hospitalist-handoffs-often-suboptimal-for-patients-with-limited-english-proficiency.htm
5 Nov 2025
Targeted tissue perfusion strategy similar to standard care for septic shock
The number of days alive with normal lactate levels and without vasopressors was similar in patients with septic shock who were randomized to a strategy allowing lower-than-recommended mean arterial pressure and those who received standard care, according to a randomized trial in Europe.
https://acphospitalist.acponline.org/archives/2025/10/29/targeted-tissue-perfusion-strategy-similar-to-standard-care-for-septic-shock.htm
29 Oct 2025
Resuscitation guidance updated by international group of experts
Updates for 2025 from the International Liaison Committee on Resuscitation address postcardiac arrest temperature management and medication use, among other topics in basic and advanced life support.
https://acphospitalist.acponline.org/archives/2025/10/29/resuscitation-guidance-updated-by-international-group-of-experts.htm
29 Oct 2025
Cefazolin noninferior to cloxacillin for MSSA bacteremia, trial finds
Cefazolin and cloxacillin showed similar efficacy, and adverse events were lower with cefazolin, according to an open-label French trial of patients with nonsevere methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia.
https://acphospitalist.acponline.org/archives/2025/10/29/cefazolin-noninferior-to-cloxacillin-for-mssa-bacteremia-trial-finds.htm
29 Oct 2025
Antihistamines linked with delirium in hospitalized older adults
Every 1% absolute increase in first-generation antihistamine prescribing by attending physicians was associated with an 8% increase in odds of delirium among their older inpatients, a cross-sectional study in Canada found.
https://acphospitalist.acponline.org/archives/2025/10/29/antihistamines-linked-with-delirium-in-hospitalized-older-adults.htm
29 Oct 2025
Strategies to avoid intraoperative hypotension didn't improve outcomes, studies find
Two recent European trials that individualized intraoperative blood pressure management based on patients' risk of hypotension did not find any difference in functional disability, mortality, or other outcomes compared to usual care.
https://acphospitalist.acponline.org/archives/2025/10/22/strategies-to-avoid-intraoperative-hypotension-didnt-improve-outcomes-studies-find.htm
22 Oct 2025
New tool designed to help with time-limited trials in end-of-life care
With consultation from patients, surrogates, and physicians, researchers developed a paper-based template to assist with discussions and decision making in the care of critically ill older adults.
https://acphospitalist.acponline.org/archives/2025/10/22/new-tool-designed-to-help-with-time-limited-trials-in-end-of-life-care.htm
22 Oct 2025
Low troponin levels predict long-term cardiovascular outcomes in chest pain patients
In patients with suspected acute coronary syndrome who were not found to have a myocardial infarction, very low levels of high-sensitivity troponin are associated with low risk of a major cardiovascular event within five years, according to a study carried out in England.
https://acphospitalist.acponline.org/archives/2025/10/22/low-troponin-levels-predict-long-term-cardiovascular-outcomes-in-chest-pain-patients.htm
22 Oct 2025
AHA statement calls for improvements in cardiac rehabilitation uptake among women
Increasing awareness and referrals, expanding access, and providing gender- and culturally sensitive programming are all potential ways to improve cardiac rehabilitation uptake among women, according to a statement from the American Heart Association (AHA).
https://acphospitalist.acponline.org/archives/2025/10/22/aha-statement-calls-for-improvements-in-cardiac-rehabilitation-uptake-among-women.htm
22 Oct 2025
Scores compared for predicting inpatient mortality in older medicine patients
A frailty score based on lab findings was a stronger predictor of inpatient mortality than one using hemoglobin, albumin, lymphocyte, and platelet levels, but both scores were associated with length of stay and likelihood of discharge to home in a retrospective Japanese study.
https://acphospitalist.acponline.org/archives/2025/10/15/scores-compared-for-predicting-inpatient-mortality-in-older-medicine-patients.htm
15 Oct 2025
Pneumonia mortality in high-risk patients no lower with broad-spectrum antibiotics than narrow
In a retrospective analysis of Japanese patients who lived in nursing homes or required home care, 30-day in-hospital mortality rates from pneumonia were similar whether they received broad- or narrow-spectrum antibiotics, including in a subgroup with additional risk factors for resistance.
https://acphospitalist.acponline.org/archives/2025/10/15/pneumonia-mortality-in-high-risk-patients-no-lower-with-broad-spectrum-antibiotics-than-narrow.htm
15 Oct 2025
Many patients are not informed about post-intensive care syndrome
Only 16.6% of former ICU patients in a U.S. survey remembered “post-intensive care syndrome” ever being mentioned to them, and 58.2% agreed that they wished they had had more conversations about recovery from critical illness before leaving the ICU.
https://acphospitalist.acponline.org/archives/2025/10/15/many-patients-are-not-informed-about-post-intensive-care-syndrome.htm
15 Oct 2025
Fluid management by hydration status may improve some outcomes in sepsis patients
In patients in South Korea with hyperosmolar dehydration at sepsis onset, initial liberal fluid management was associated with improved lactate levels without worsening Sequential Organ Failure Assessment score but no change in 30-day mortality risk.
https://acphospitalist.acponline.org/archives/2025/10/15/fluid-management-by-hydration-status-may-improve-some-outcomes-in-sepsis-patients.htm
15 Oct 2025
Study finds AI-generated discharge summaries superior to those written by humans
Discharge summaries generated by a large language model at a tertiary care center scored better on nine domains, including comprehensiveness, relevance, and specificity, according to physician reviewers. Those written by humans did use simpler language.
https://acphospitalist.acponline.org/archives/2025/10/08/study-finds-ai-generated-discharge-summaries-superior-to-those-written-by-humans.htm
8 Oct 2025
In-hospital delirium risk varies by race, socioeconomic status
Older hospitalized adults who were Black or Hispanic were more likely to have delirium at admission or to develop it during their hospital stay than White patients, a retrospective analysis of more than 260,000 patients found.
https://acphospitalist.acponline.org/archives/2025/10/08/in-hospital-delirium-risk-varies-by-race-socioeconomic-status.htm
8 Oct 2025
Factors predict patients being infected with C. auris rather than just colonized
Comorbid conditions, invasive devices, and recent procedures were all associated with risk of progressing from Candida auris colonization to infection, a retrospective study of Florida patients found.
https://acphospitalist.acponline.org/archives/2025/10/08/factors-predict-patients-being-infected-with-c-auris-rather-than-just-colonized.htm
8 Oct 2025
Biomarker shows promise for longer-term risk prediction in cardiac ED patients
Growth differentiation factor-15 predicted risk of death or acute myocardial infarction (AMI) within 90 days in patients who were seen in the ED for suspected AMI but did not have an elevated troponin level at the time, an industry-funded study found.
https://acphospitalist.acponline.org/archives/2025/10/08/biomarker-shows-promise-for-longer-term-risk-prediction-in-cardiac-ed-patients.htm
8 Oct 2025