Search results for "Research Summaries"
SNRIs associated with improved outcomes from Takotsubo cardiomyopathy
Patients who were on serotonin–norepinephrine reuptake inhibitors (SNRIs) and developed Takotsubo cardiomyopathy were less likely to die at seven days and one year, a propensity-matched cohort study found.
https://acphospitalist.acponline.org/archives/2025/07/02/snris-associated-with-improved-outcomes-from-takotsubo-cardiomyopathy.htm
2 Jul 2025
Early invasive strategy doesn't improve mortality in older adults with ACS, review finds
In older patients with acute coronary syndrome (ACS), an early invasive strategy was associated with lower risk of recurrent myocardial infarction and repeated coronary revascularization but increased risk of major bleeding compared to a conservative strategy, a meta-analysis concluded.
https://acphospitalist.acponline.org/archives/2025/07/02/early-invasive-strategy-doesnt-improve-mortality-in-older-adults-with-acs-review-finds.htm
2 Jul 2025
Critically ill AMI patients who got morphine had higher mortality, study finds
A retrospective analysis of patients in the ICU after an acute myocardial infarction (AMI) found that receipt of opioids in general was associated with mortality, but after adjustment, the link was isolated to morphine specifically.
https://acphospitalist.acponline.org/archives/2025/07/02/critically-ill-ami-patients-who-got-morphine-had-higher-mortality-study-finds.htm
2 Jul 2025
Catheter ablation beat medications, cardioversion, lifestyle for afib in recent studies
A recent trial compared catheter ablation to lifestyle modification plus rate and/or rhythm medications in patients with atrial fibrillation and obesity, while a meta-analysis compiled trials that compared catheter or surgical ablation to other interventions for atrial fibrillation.
https://acphospitalist.acponline.org/archives/2025/07/02/catheter-ablation-beat-medications-cardioversion-lifestyle-for-afib-in-recent-studies.htm
2 Jul 2025
No difference in mortality, readmission risk with lactated Ringer's vs. normal saline
In an open-label trial, seven Canadian hospitals used lactated Ringer's solution for 12 weeks and seven used normal saline. Then they switched. Patient outcomes didn't vary significantly by which fluid was used.
https://acphospitalist.acponline.org/archives/2025/06/25/no-difference-in-mortality-readmission-risk-with-lactated-ringers-vs-normal-saline.htm
25 Jun 2025
Most septic shock patients had AKI at admission, later recovered kidney function
Having stage 1 acute kidney injury (AKI) was not associated with any increase in mortality risk for septic shock patients, but having stage 2 or 3 AKI did increase risk, a retrospective study found. The kidneys fully recovered in 88.2%, 78.5%, and 63.2% of patients with stage 1, 2, and 3 AKI, respectively.
https://acphospitalist.acponline.org/archives/2025/06/25/most-septic-shock-patients-had-aki-at-admission-later-recovered-kidney-function.htm
25 Jun 2025
Low score on LKA associated with higher patient mortality, ABIM study finds
An analysis of hospitalists participating in the American Board of Internal Medicine (ABIM) Longitudinal Knowledge Assessment (LKA) found that those with scores in the bottom quartile had more patients who died or were readmitted within seven days than those who scored higher.
https://acphospitalist.acponline.org/archives/2025/06/25/low-score-on-lka-associated-with-higher-patient-mortality-abim-study-finds.htm
25 Jun 2025
Early anti-enterococcal empirical therapy may not improve survival in BSI
Having more comorbid conditions or an enterococcal bloodstream infection (BSI) without an identified source independently predicted 14- and 30-day mortality, but receiving early empiric therapy did not, according to a retrospective cohort study in Italy and Spain.
https://acphospitalist.acponline.org/archives/2025/06/25/early-anti-enterococcal-empirical-therapy-may-not-improve-survival-in-bsi.htm
25 Jun 2025
Most inpatients not using hospital patient portal, study finds
Fewer than one-third of patients had an active account on the patient portal during hospitalization, and only slightly more than half of those accessed their portal while admitted, a single-center study found.
https://acphospitalist.acponline.org/archives/2025/06/18/most-inpatients-not-using-hospital-patient-portal-study-finds.htm
18 Jun 2025
Fecal transplant noninferior to vancomycin for first C. diff infection, trial finds
The Clostridioides difficile cure rate was statistically noninferior and numerically higher in patients randomized to fecal microbiota transplantation instead of vancomycin for an initial C. difficile infection, a small open-label trial in Norway found.
https://acphospitalist.acponline.org/archives/2025/06/18/fecal-transplant-noninferior-to-vancomycin-for-first-c-diff-infection-trial-finds.htm
18 Jun 2025
Conservative oxygen therapy in the ICU does not reduce 90-day mortality, trial finds
In ventilated patients, no differences were seen in mortality or length of stay between patients randomized to a peripheral oxygen saturation target of 90% and those who received usual care, a clinical trial in the United Kingdom found.
https://acphospitalist.acponline.org/archives/2025/06/18/conservative-oxygen-therapy-in-the-icu-does-not-reduce-90-day-mortality-trial-finds.htm
18 Jun 2025
Augmenting protein in enteral nutrition didn't improve outcomes
ICU patients randomized to an enteral formula with 100 g of protein per L had no more days alive and out of the hospital than patients who got a standard formula, a large open-label trial in Australia and New Zealand found.
https://acphospitalist.acponline.org/archives/2025/06/18/augmenting-protein-in-enteral-nutrition-didnt-improve-outcomes.htm
18 Jun 2025
Sodium plus diuretics may improve outcomes in acute decompensated heart failure
Kidney function, weight loss, and length of stay were better in patients hospitalized with decompensated heart failure who received sodium supplementation with diuretics, according to a systematic review and meta-analysis.
https://acphospitalist.acponline.org/archives/2025/06/11/sodium-plus-diuretics-may-improve-outcomes-in-acute-decompensated-heart-failure.htm
11 Jun 2025
Liberal RBC transfusion threshold doesn't improve quality of life in MI with anemia
Compared to a restrictive red blood cell (RBC) transfusion strategy, a liberal threshold for transfusion in patients with myocardial infarction (MI) and anemia did not result in significantly different quality of life, according to a new analysis of a randomized trial.
https://acphospitalist.acponline.org/archives/2025/06/11/liberal-rbc-transfusion-threshold-doesnt-improve-quality-of-life-in-mi-with-anemia.htm
11 Jun 2025
RSV, flu increase risk of secondary S. pneumoniae infection, COVID-19 doesn't, study finds
Having tested positive for influenza or respiratory syncytial virus (RSV) in the past 30 days more than doubled the risk of subsequent Streptococcus pneumoniae infection, but COVID-19 was associated with a decreased risk, according to retrospective data from more than 188,000 hospitalized veterans tested for S. pneumoniae.
https://acphospitalist.acponline.org/archives/2025/06/11/free/rsv-flu-increase-risk-of-secondary-s-pneumoniae-infection-covid-19-doesnt-study-finds.htm
11 Jun 2025
Boarding in the ED on the rise before, worsened during pandemic, study finds
In January 2022, when rates of ED boarding in U.S. hospitals peaked, 40.1% of hospitalized patients boarded in an ED for longer than four hours and 6.3% for longer than 24 hours, a cross-sectional analysis of more than 40 million hospitalizations found.
https://acphospitalist.acponline.org/archives/2025/06/11/boarding-in-the-ed-on-the-rise-before-worsened-during-pandemic-study-finds.htm
11 Jun 2025
New guidelines on platelet transfusions support restrictive strategies for many patients
The Association for the Advancement of Blood and Biotherapies and the International Collaboration for Transfusion Medicine Guidelines updated their recommendations for 2025.
https://acphospitalist.acponline.org/archives/2025/06/04/new-guidelines-on-platelet-transfusions-support-restrictive-strategies-for-many-patients.htm
4 Jun 2025
Hybrid HaH model found to be safe alternative to traditional inpatient care
Rates of 30-day all-cause mortality and unplanned readmissions were similar in patients assigned to a virtual hybrid hospital at home (HaH) program and those assigned to brick-and-mortar hospital care, with higher patient comfort in the former group, according to a randomized trial.
https://acphospitalist.acponline.org/archives/2025/06/04/hybrid-hah-model-found-to-be-safe-alternative-to-traditional-inpatient-care.htm
4 Jun 2025
High inpatient mortality rate, disparities in incidence with candidemia in recent years
Bloodstream infections from Candida species were consistently more common in patients who were ages 65 years or older and in Black patients, and more than 60% of these infections occurred when a patient had a central line, according to CDC data from 2017 to 2021.
https://acphospitalist.acponline.org/archives/2025/06/04/high-inpatient-mortality-rate-disparities-in-incidence-with-candidemia-in-recent-years.htm
4 Jun 2025
Cognitive outcomes similar between perioperative blood pressure strategies
A randomized controlled trial compared the effect of hypotension avoidance versus hypertension avoidance on delirium and one-year cognitive decline after noncardiac surgery.
https://acphospitalist.acponline.org/archives/2025/06/04/cognitive-outcomes-similar-between-perioperative-blood-pressure-strategies.htm
4 Jun 2025