Search results for "Antibiotics"
Review finds limited evidence to support oral antibiotics in S. aureus bacteremia, endocarditis
Rates of treatment failure and adverse events were similar among patients with Staphylococcus aureus who were randomized to fully IV treatment versus at least some oral antibiotics, but only four trials were judged eligible for inclusion by the authors of a recent meta-analysis.
https://acphospitalist.acponline.org/archives/2024/09/25/review-finds-limited-evidence-to-support-oral-antibiotics-in-s-aureus-bacteremia-endocarditis.htm
25 Sep 2024
Deaths from antimicrobial resistance could rise by nearly 70% by 2050, study finds
Between 1990 and 2021, deaths from antimicrobial resistance decreased by more than 50% among children under age five years but increased by more than 80% among adults ages 70 years and older, a global study found.
https://acphospitalist.acponline.org/archives/2024/09/25/deaths-from-antimicrobial-resistance-could-rise-by-nearly-70percent-by-2050-study-finds.htm
25 Sep 2024
Antibiotics with extended anaerobic coverage didn't improve outcomes in aspiration pneumonia
Patients with aspiration pneumonia who received extended anaerobic coverage had no reduction in mortality risk and a significantly higher risk of Clostridioides difficile than those prescribed limited anaerobic coverage.
https://acphospitalist.acponline.org/archives/2024/02/28/antibiotics-with-extended-anaerobic-coverage-didnt-improve-outcomes-in-aspiration-pneumonia.htm
28 Feb 2024
New combo antibiotic shows success against complicated urinary tract infections
Microbiologic and clinical recovery occurred in 70.6% of hospitalized patients randomized to an investigational beta-lactam and beta-lactamase inhibitor combination for urinary tract infection compared to 58% of patients given meropenem, an industry-funded trial found.
https://acphospitalist.acponline.org/archives/2024/02/21/new-combo-antibiotic-shows-success-against-complicated-urinary-tract-infections.htm
21 Feb 2024
Hospital clinicians don't often use antibiograms when prescribing, survey finds
Among 193 respondents from seven U.S. health care systems, 26.9% of hospital clinicians said they used antibiograms more than once a month and 16.1% did not know that their facility had an antibiogram available.
https://acphospitalist.acponline.org/archives/2024/02/21/hospital-clinicians-dont-often-use-antibiograms-when-prescribing-survey-finds.htm
21 Feb 2024
Switch to oral antibiotics noninferior for low-risk patients with S. aureus bacteremia
Complication rates were similar in patients with low-risk Staphylococcus aureus bloodstream infection who were switched to oral antibiotics versus continued on IV therapy in a European randomized trial that was stopped early due to low enrollment.
https://acphospitalist.acponline.org/archives/2024/01/24/switch-to-oral-antibiotics-noninferior-for-low-risk-patients-with-s-aureus-bacteremia.htm
24 Jan 2024
De-escalation of antibiotics effective in Enterobacterales bacteremia, Spanish trial finds
The pragmatic trial found similarly high cure rates and no difference in serious adverse events between patients who continued on an antipseudomonal beta-lactam and those de-escalated to an antibiotic without antipseudomonal activity.
https://acphospitalist.acponline.org/archives/2024/01/17/de-escalation-of-antibiotics-effective-in-enterobacterales-bacteremia-spanish-trial-finds.htm
17 Jan 2024
Adverse effects of antibiotics compared for patients hospitalized with infection
A randomized clinical trial at one academic medical center in the U.S. found that piperacillin-tazobactam and cefepime carried similar risk of acute kidney injury but cefepime was associated with more neurological dysfunction.
https://acphospitalist.acponline.org/archives/2023/10/18/adverse-effects-of-antibiotics-compared-for-patients-hospitalized-with-infection.htm
18 Oct 2023
Phase 3 trial finds new antibiotic noninferior to daptomycin for MRSA
An industry-funded trial compared ceftobiprole, a cephalosporin, to daptomycin plus optional aztreonam in adults with complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus (MRSA).
https://acphospitalist.acponline.org/archives/2023/10/04/phase-3-trial-finds-new-antibiotic-noninferior-to-daptomycin-for-mrsa.htm
4 Oct 2023
Antibiotic regimens differ in associated risk of AKI in critically ill patients
Vancomycin and piperacillin/tazobactam were associated with a higher risk of acute kidney injury (AKI) than either vancomycin and cefepime or vancomycin and meropenem in ICU patients, particularly at longer durations and in those with normal kidney function on admission.
https://acphospitalist.acponline.org/archives/2023/04/19/antibiotic-regimens-differ-in-associated-risk-of-aki-in-critically-ill-patients.htm
19 Apr 2023
Few low-risk inpatients with CAP switched from IV to oral therapy
Patients hospitalized with community-acquired pneumonia (CAP) who transitioned from IV to oral antibiotics by day 3 had shorter length of stay and lower hospitalization cost than those who did not, with no increase in 14-day mortality or ICU admission, a retrospective study found.
https://acphospitalist.acponline.org/archives/2023/04/12/few-low-risk-inpatients-with-cap-switched-from-iv-to-oral-therapy.htm
12 Apr 2023
Advice from ACP supports short courses of antibiotics for several common infections
Because at least 30% of antibiotic use is considered unnecessary, best practices were issued on treatment of chronic obstructive pulmonary disease exacerbation and uncomplicated bronchitis, community-acquired pneumonia, uncomplicated urinary tract infection, and cellulitis.
https://acphospitalist.acponline.org/weekly/archives/2021/04/07/4.htm
7 Apr 2021
CRP-guided or 7-day regimens noninferior to 14 days of antibiotics for bacteremia
While rates of clinical failure for C-reactive protein (CRP)-guided antibiotic treatment duration and fixed seven-day treatment were noninferior to fixed 14-day treatment in a randomized trial, interpretation of the results was limited by a large noninferiority margin and low event rate.
https://acphospitalist.acponline.org/weekly/archives/2020/06/10/4.htm
10 Jun 2020
Macrolide antibiotics may be associated with cardiovascular complications, deaths
Treatment with macrolides is associated with 38.2 additional cardiovascular deaths per 1 million treatment courses, according to a new meta-analysis, but no increase in all-cause mortality was found.
https://acphospitalist.acponline.org/weekly/archives/2015/11/11/4.htm
11 Nov 2015
Azithromycin, levofloxacin associated with increased cardiac risk versus amoxicillin
Azithromycin and levofloxacin were both associated with increased cardiac risk compared with amoxicillin, a recent study found.
https://acphospitalist.acponline.org/weekly/archives/2014/03/19/5.htm
19 Mar 2014
Azithromycin associated with more cardiac, all-cause mortality
Taking azithromycin can increase one's risk of cardiovascular death, especially for patients who have a high baseline risk of cardiovascular disease, a new study found.
https://acphospitalist.acponline.org/weekly/archives/2012/05/23/5.htm
23 May 2012