Search results for "Sepsis"
Ultra-short-acting beta-blockers may not reduce mortality in sepsis, meta-analysis finds
A meta-analysis of trials of esmolol or landiolol in patients with sepsis found use of these beta-blockers was associated with a nonsignificant reduction in mortality versus placebo or standard care, highlighting the fragility of research in this area.
https://acphospitalist.acponline.org/archives/2024/09/04/ultra-short-acting-beta-blockers-may-not-reduce-mortality-in-sepsis-meta-analysis-finds.htm
4 Sep 2024
Moderate IV fluid resuscitation associated with less sepsis mortality
An industry-funded analysis of ICU patients admitted with sepsis and septic shock found that those who received a moderate amount of IV fluid on day 1 had a 2.5% reduction in mortality compared with those treated with very low or very high amounts of fluid.
https://acphospitalist.acponline.org/archives/2024/08/28/moderate-iv-fluid-resuscitation-associated-with-less-sepsis-mortality.htm
28 Aug 2024
Earlier norepinephrine for septic shock appears safe, possibly beneficial, review finds
Although earlier administration of norepinephrine in patients with septic shock was not associated with a significant reduction in overall mortality, it was linked with reduced incidence of pulmonary edema, a review and meta-analysis of 12 studies found.
https://acphospitalist.acponline.org/archives/2024/07/17/earlier-norepinephrine-for-septic-shock-appears-safe-possibly-beneficial-review-finds.htm
17 Jul 2024
New model risk-adjusts sepsis patients for better mortality measurement
The model includes 13 physiologic variables, two physiologic interactions, and 16 demographic and chronic health variables, the most significant being age, metastatic solid tumor, temperature, altered mental status, and platelet count, and could be used to assess sepsis care, researchers said.
https://acphospitalist.acponline.org/archives/2024/07/10/new-model-risk-adjusts-sepsis-patients-for-better-mortality-measurement.htm
10 Jul 2024
Sepsis order sets linked with improved outcomes, lower hospital costs
Order sets for sepsis care were associated with a 3.3% lower hospital mortality rate among sepsis patients and a $1,487 lower median direct variable total cost, according to one hospital's matched analysis of patients treated with or without an order set.
https://acphospitalist.acponline.org/archives/2024/06/26/sepsis-order-sets-linked-with-improved-outcomes-lower-hospital-costs.htm
26 Jun 2024
Continuous infusion may provide benefit over intermittent in antibiotics for sepsis
A new randomized trial found a nonsignificant decrease in mortality with continuous infusion of beta-lactams for ICU patients with sepsis, but a new review that included the study showed a significant effect on mortality and cure rates with prolonged versus intermittent infusion.
https://acphospitalist.acponline.org/archives/2024/06/19/continuous-infusion-may-provide-benefit-over-intermittent-in-antibiotics-for-sepsis.htm
19 Jun 2024
Beta-lactam de-escalation associated with lower risk of new drug resistance in sepsis
Hospitalized patients with sepsis were less likely to develop new drug-resistant, gram-negative bacteria within 60 days if their antibiotics were de-escalated (according to a beta-lactam spectrum score) rather than continued at the same level, a retrospective study found.
https://acphospitalist.acponline.org/archives/2024/06/19/beta-lactam-de-escalation-associated-with-lower-risk-of-new-drug-resistance-in-sepsis.htm
19 Jun 2024
Wide variation in sepsis outcomes by site of infection, type of organ dysfunction
One-fifth of inpatients diagnosed with sepsis met organ dysfunction criteria solely because of a decline in their systolic blood pressure, one of several findings leading the authors of a new study to propose reconsideration of the definition of sepsis.
https://acphospitalist.acponline.org/archives/2024/05/29/wide-variation-in-sepsis-outcomes-by-site-of-infection-type-of-organ-dysfunction.htm
29 May 2024
IV acetaminophen did not reduce mortality in ICU patients with sepsis
Acetaminophen did appear to be safe and associated with lower rates of acute respiratory distress syndrome when compared with placebo in a randomized trial of critically ill sepsis patients at 40 U.S. hospitals.
https://acphospitalist.acponline.org/archives/2024/05/29/iv-acetaminophen-did-not-reduce-mortality-in-icu-patients-with-sepsis.htm
29 May 2024
Cefepime associated with lower mortality than pip-tazo in sepsis, retrospective study finds
Among patients with sepsis, a treatment regimen of vancomycin and piperacillin-tazobactam was associated with a 5% increase in 90-day mortality compared with vancomycin plus cefepime, according to one hospital's analysis of a piperacillin-tazobactam shortage period.
https://acphospitalist.acponline.org/archives/2024/05/22/cefepime-associated-with-lower-mortality-than-pip-tazo-in-sepsis-retrospective-study-finds.htm
22 May 2024
Position paper calls on CMS to revise plan to pay for sepsis performance
Paying hospitals based on the SEP-1 bundle would divert attention and resources from more effective ways to provide comprehensive sepsis care, said medical groups including the Infectious Diseases Society of America and the Society of Hospital Medicine.
https://acphospitalist.acponline.org/archives/2023/10/25/position-paper-calls-on-cms-to-revise-plan-to-pay-for-sepsis-performance.htm
25 Oct 2023
Sepsis can be classified into hypo- and hyperinflammatory phenotypes, researchers say
About a third of sepsis patients fit a hyperinflammatory phenotype, and they were more likely to benefit from activated protein C than those with a hypoinflammatory phenotype, a new analysis of existing study data found.
https://acphospitalist.acponline.org/archives/2023/08/30/sepsis-can-be-classified-into-hypo-and-hyperinflammatory-phenotypes-researchers-say.htm
30 Aug 2023
Time to antibiotics matters for septic shock, not so much for sepsis without shock
Every hour that antibiotics were delayed was associated with higher mortality from septic shock, but patients with sepsis and no shock only had elevated risk of death if their antibiotics were not administered within six hours, according to a new analysis.
https://acphospitalist.acponline.org/archives/2023/08/09/time-to-antibiotics-matters-for-septic-shock-not-so-much-for-sepsis-without-shock.htm
9 Aug 2023
Continuous vs. intermittent meropenem administration did not improve outcomes in sepsis
A composite outcome of mortality and new antimicrobial resistance did not differ by whether critically ill patients received an equal dose of the beta-lactam antibiotic continuously or intermittently, an international randomized trial found.
https://acphospitalist.acponline.org/archives/2023/06/21/continuous-vs-intermittent-meropenem-administration-did-not-improve-outcomes-in-sepsis.htm
21 Jun 2023
Review finds no significant difference between IV fluid strategies in sepsis
A systematic review and meta-analysis of 13 trials found that all-cause mortality and rates of serious adverse events did not seem to vary by whether sepsis patients received lower or higher fluid volumes.
https://acphospitalist.acponline.org/archives/2023/05/10/review-finds-no-significant-difference-between-iv-fluid-strategies-in-sepsis.htm
10 May 2023
Septic shock outcomes better in patients who got hydrocortisone plus fludrocortisone
A retrospective analysis of patients hospitalized with septic shock and receiving norepinephrine found that 47.2% of those who began hydrocortisone and fludrocortisone simultaneously died in the hospital or were discharged to hospice, compared to 50.8% of those treated with hydrocortisone alone.
https://acphospitalist.acponline.org/archives/2023/04/05/septic-shock-outcomes-better-in-patients-who-got-hydrocortisone-plus-fludrocortisone.htm
5 Apr 2023
Nearly 10% of ED patients meeting Sepsis-3 criteria did not have true infection
Of 812 patients meeting Sepsis-3 criteria in four studied EDs, 79 (9.7%) had only possible infection and 77 (9.5%) were not infected, according to later adjudication of the records by trained nonclinician reviewers.
https://acphospitalist.acponline.org/archives/2023/03/01/nearly-10-of-ed-patients-meeting-sepsis-3-criteria-did-not-have-true-infection.htm
1 Mar 2023
Sepsis associated with higher cardiovascular risk after hospitalization
A retrospective cohort analysis of 2.25 million U.S. patients found that those with sepsis were at higher risk for all-cause mortality and rehospitalization for each major type of cardiovascular disease event, particularly heart failure, than those without.
https://acphospitalist.acponline.org/archives/2023/02/08/sepsis-associated-with-higher-cardiovascular-risk-after-hospitalization.htm
8 Feb 2023
Mortality similar with restrictive vs. liberal fluid strategies for sepsis with hypotension
A multicenter U.S. trial randomized patients with sepsis-induced hypotension to either a strategy prioritizing vasopressors and lower IV fluid volumes or a strategy prioritizing higher volumes of IV fluids before vasopressors for 24 hours after initial treatment.
https://acphospitalist.acponline.org/archives/2023/02/01/free/mortality-similar-with-restrictive-vs-liberal-fluid-strategies-for-sepsis-with-hypotension.htm
1 Feb 2023
Opt-out protocol increased antibiotic discontinuations in suspected sepsis
Inpatients on broad-spectrum antibiotics despite negative blood cultures were screened with a 23-item safety check and then randomized to usual care or messages to their prescribing clinicians encouraging discontinuation of antibiotics.
https://acphospitalist.acponline.org/archives/2022/10/05/opt-out-protocol-increased-antibiotic-discontinuations-in-suspected-sepsis.htm
5 Oct 2022