Search results for "Antibiotic Therapy"
Asymptomatic bacteriuria treatment averted due to fewer urine cultures, study finds
Michigan hospitals successfully reduced their use of antibiotics in asymptomatic patients with positive urine cultures, and the difference could be tied to less culturing, since use of antibiotics among asymptomatic patients who got cultures didn't change significantly.
https://acphospitalist.acponline.org/archives/2023/07/12/asymptomatic-bacteriuria-treatment-averted-due-to-fewer-urine-cultures-study-finds.htm
12 Jul 2023
Procalcitonin do's and don'ts
Although the optimal use of procalcitonin is still up for debate, there are best practices for getting the most bang for this blood test.
https://acphospitalist.acponline.org/archives/2023/07/05/free/procalcitonin-dos-and-donts.htm
5 Jul 2023
Procalcitonin algorithm reduced antibiotic use in COVID-19 inpatients
A Dutch intervention used procalcitonin levels in inpatients with COVID-19 to guide antibiotic use, with an algorithm discouraging prescriptions if levels were less than 0.25 ng/mL and recommending antibiotics for patients with levels above 0.5 ng/mL.
https://acphospitalist.acponline.org/archives/2023/05/03/free/procalcitonin-algorithm-reduced-antibiotic-use-in-covid-19-inpatients.htm
3 May 2023
Antibiotic regimens differ in associated risk of AKI in critically ill patients
Vancomycin and piperacillin/tazobactam were associated with a higher risk of acute kidney injury (AKI) than either vancomycin and cefepime or vancomycin and meropenem in ICU patients, particularly at longer durations and in those with normal kidney function on admission.
https://acphospitalist.acponline.org/archives/2023/04/19/antibiotic-regimens-differ-in-associated-risk-of-aki-in-critically-ill-patients.htm
19 Apr 2023
Inpatient oral penicillin challenge more likely in certain low-risk patients
An inpatient penicillin allergy program showed that patients were more likely to proceed from assessment to oral challenge if they had a low-risk phenotype, had an indication for beta-lactam antibiotic therapy, and were medically stable.
https://acphospitalist.acponline.org/archives/2023/03/29/inpatient-oral-penicillin-challenge-more-likely-in-certain-low-risk-patients.htm
29 Mar 2023
Similar odds of recurrence with 10 vs. 14 days of antibiotics for complicated UTI with bacteremia
A study of 24 U.S. hospitals also found that in patients with complicated urinary tract infection (UTI) who receive beta-lactams or highly bioavailable oral agents, a seven-day course may be sufficient.
https://acphospitalist.acponline.org/archives/2023/01/25/similar-odds-of-recurrence-with-10-vs-14-days-of-antibiotics-for-complicated-uti-with-bacteremia.htm
25 Jan 2023
Appropriate antibiotics for CAP linked to lower 1-year cardiovascular death risk in older inpatients
A Canadian study of nearly 2,000 patients older than age 65 years who were hospitalized with community-acquired pneumonia (CAP) found that use of guideline-concordant antibiotic therapy was associated with a 47% reduction in cardiovascular death at one year after infection.
https://acphospitalist.acponline.org/archives/2023/01/11/appropriate-antibiotics-for-CAP-linked-to-lower-1-year-cardiovascular-death-risk-in-older-inpatients.htm
11 Jan 2023
Oral antibiotics after incomplete IV therapy showed benefit in patients with history of injection drug use
Among persons who inject drugs who were hospitalized with complicated Staphylococcus aureus bloodstream infections, those who received oral antibiotics after an incomplete IV antibiotic course were significantly less likely to experience microbiologic failure or death than patients discharged without oral antibiotics.
https://acphospitalist.acponline.org/archives/2022/09/14/oral-antibiotics-after-incomplete-iv-therapy-showed-benefit-in-patients-with-history-of-injection-drug-use.htm
14 Sep 2022
OPAT has similar safety, lower costs versus inpatient antibiotic therapy
Patients receiving outpatient parenteral antimicrobial therapy (OPAT) after hospitalization for bacterial infection had 90-day adverse event rates of 35.6% compared to 39.0% in those who stayed in the hospital for parenteral antimicrobial therapy, a retrospective Canadian study found.
https://acphospitalist.acponline.org/archives/2022/04/27/opat-has-similar-safety-lower-costs-versus-inpatient-antibiotic-therapy.htm
27 Apr 2022
Gram stain-guided antibiotics for VAP noninferior to guideline-based therapy
Compared with guideline-based treatment, treatment guided by Gram staining significantly reduced use of broad-spectrum antibiotics and yielded similar clinical responses in patients with ventilator-associated pneumonia (VAP), a Japanese trial found.
https://acphospitalist.acponline.org/archives/2022/04/13/gram-stain-guided-antibiotics-for-vap-noninferior-to-guideline-based-therapy.htm
13 Apr 2022