Search results for "C. difficile"
Stopping the cycle of C. diff
Microbiota therapies offer exciting potential to reduce the burden of recurrent Clostridioides difficile infection, experts say.
https://acphospitalist.acponline.org/archives/2023/02/08/free/stopping-the-cycle-of-c-diff.htm
8 Feb 2023
Most asymptomatic C. difficile carriers in health care settings did not progress to infection
In a study at three U.S. hospitals and affiliated long-term care facilities, most patients who were found to be carriers of Clostridioides difficile had cleared the bacteria on subsequent testing, and only 13.4% were subsequently diagnosed with infection.
https://acphospitalist.acponline.org/archives/2023/03/22/most-asymptomatic-c-difficile-carriers-in-health-care-settings-did-not-progress-to-infection.htm
22 Mar 2023
Mandatory approval process for C. diff testing linked to lower hospital-onset infection rates
An intervention that required mandatory approval from an infectious diseases physician before testing for Clostridioides difficile was associated with a greater than 50% decrease in hospital-onset C. difficile infection rates at one hospital.
https://acphospitalist.acponline.org/archives/2023/05/17/mandatory-approval-process-for-c-diff-testing-linked-to-lower-hospital-onset-infection-rates.htm
17 May 2023
Two-step testing for Clostridioides difficile appears safe in multicenter study
Using an enzyme immunoassay after a positive nucleic acid amplification test was associated with a decrease in hospital-onset Clostridioides difficile infections and a reduction in related antibiotic use but no change in emergent colectomies.
https://acphospitalist.acponline.org/archives/2023/06/14/two-step-testing-for-clostridioides-difficile-appears-safe-in-multicenter-study.htm
14 Jun 2023
Catching C. diff cases, not colonization
Researchers have found innovative ways to improve hospital systems for diagnosing Clostridioides difficile.
https://acphospitalist.acponline.org/archives/2023/08/16/catching-c-diff-cases-not-colonization.htm
16 Aug 2023
Patients with discordant C. difficile test results had lower mortality with treatment
Patients who were positive for Clostridioides difficile on nucleic acid amplification testing but negative on toxin immunoassay had similar 30-day mortality to those with positive results on both tests, according to a review of observational studies.
https://acphospitalist.acponline.org/archives/2023/09/13/patients-with-discordant-c-difficile-test-results-had-lower-mortality-with-treatment.htm
13 Sep 2023
Doxycycline for CAP associated with lower C. diff risk than azithromycin
In a retrospective study of community-acquired pneumonia (CAP) patients, treatment with doxycycline instead of azithromycin was associated with a particularly significant reduction in risk of Clostridioides difficile infection among those who had already had C. diff within the past year.
https://acphospitalist.acponline.org/archives/2023/11/08/doxycycline-for-cap-associated-with-lower-c-diff-risk-than-azithromycin.htm
8 Nov 2023
Antibiotics with extended anaerobic coverage didn't improve outcomes in aspiration pneumonia
Patients with aspiration pneumonia who received extended anaerobic coverage had no reduction in mortality risk and a significantly higher risk of Clostridioides difficile than those prescribed limited anaerobic coverage.
https://acphospitalist.acponline.org/archives/2024/02/28/antibiotics-with-extended-anaerobic-coverage-didnt-improve-outcomes-in-aspiration-pneumonia.htm
28 Feb 2024